By Atash Javaherian, Pasha Latifpour
This e-book provides present examine within the examine of the homes, medical makes use of and hostile results of acetaminophen. themes mentioned contain complicated equipment for the elimination of acetaminophen from the water provide; acetaminophen overdose, biomarkers and administration; acetaminophen hepatotoxicity and capability interactions with supplements; and, sesame oil and sesamol for treating acetaminophen-overdose-associated liver accidents and paracetamol use within the aged.
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Extra info for Acetaminophen : properties, clinical uses and adverse effects
This is not surprising since the liver plays an important role in normal thermoregulation as a major heat-producing organ as well as by providing metabolic substrates for other organs and tissues (81). Accordingly, the development of hypothermia is a major feature in surgical models involving hepatic devascularisation or total hepatectomy in small as well as in large animal species (82-84). Figure 2. Effects of APAP administration on mouse body temperature. p. injection of either 150 mg/kg bw, 300 mg/kg bw or 600 mg/kg bw of APAP.
1983 Jan;33(1):95-101.  Arnman R, Olsson R. Elimination of paracetamol in chronic liver disease. Acta Hepatogastroenterol (Stuttg). 1978 Aug;25(4):283-6.  Andreasen PB, Hutters L. Paracetamol (acetaminophen) clearance in patients with cirrhosis of the liver. Acta Med Scand Suppl. 1979;624:99-105.  Benson GD, Koff RS, Tolman KG. The therapeutic use of acetaminophen in patients with liver disease. Am J Ther. 2005 Mar-Apr;12(2):133-41.  Bailie GR, Mason NA, Bragg-Gresham JL, Gillespie BW, Young EW.
Safety and pharmacokinetics of paracetamol following intravenous administration of 5 g during the first 24 h with a 2-g starting dose. Clin Pharmacol Ther. 2007 Mar;81(3):401-5. In: Acetaminophen: Properties, Clinical Uses Editors: Atash Javaherian and Pasha Latifpour ISBN: 978-1-61942-374-9 © 2012 Nova Science Publishers, Inc. Chapter 2 CLINICAL AND EXPERIMENTAL RELEVANCE OF HYPOTHERMIA IN ACETAMINOPHEN HEPATOTOXICITY José I. Fortea1, Javier Vaquero1, and Roger F. Butterworth2* 1 Laboratorio de Investigación en Hepatología y Gastroenterología del Hospital Gregorio Marañón-CIBERehd, Madrid, Spain 2 Neuroscience Research Unit, Hôpital Saint-Luc (CHUM), University of Montreal, Montreal, QC, Canada ABSTRACT Acetaminophen (APAP) overdose frequently results in the development of severe liver injury in both humans and experimental animals.
Acetaminophen : properties, clinical uses and adverse effects by Atash Javaherian, Pasha Latifpour